The preclinical data revealed that S23 is the most suppressive SARM in development and resulted in infertility in all rats treated.Įxpectedly, this raised interest in its potential clinical applications as a form of male birth control. This means that S23 can be administered orally, as opposed to requiring injections to achieve maximal blood serum concentration levels, which is obviously advantageous when it comes to ease of use and adoption. The closer a SARM is to 100% the closer it is to complete absorption after oral dosing. Pharmacokinetic studies showed that C-6 is 76% orally bioavailable, and by swapping the para-nitro group for a cyano group S23 is able to achieve 96% oral bioavailability. S23 was created by modifying the structure of an older and less efficacious SARM called C-6 by changing the para-nitro group of C-6 to a cyano group. S23 exhibits a high affinity for the androgen receptor with tissue selective anabolic effects in muscle in bone, with relatively less stimulation of the prostate, seminal vesicles, and other androgen affected tissues. It is still in the preclinical stage of development, meaning it has only been tested on animals, not humans. S23 is a selective androgen receptor modulator (SARM) currently under development for potential use as a male hormonal contraceptive. S23 Reviews (Anecdotal/Recreational Reports).Increases Muscle Mass And Bone Mineral Density.
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